Large-scale placenta DNA methylation integrated analysis reveals fetal sex-specific differentially methylated CpG sites and regions
| Autor: | Shan V, Andrews, Irene J, Yang, Karolin, Froehlich, Tomiko, Oskotsky, Marina, Sirota |
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| Rok vydání: | 2022 |
| Předmět: |
Male
Pediatric Sex Characteristics Multidisciplinary Placenta 1.1 Normal biological development and functioning Human Genome Reproductive health and childbirth DNA Methylation Epigenesis Genetic Promoter Regions Genetic Pregnancy Genetics Humans CpG Islands Female Promoter Regions Genetic Epigenesis |
| Zdroj: | Scientific reports, vol 12, iss 1 |
| Popis: | Although male–female differences in placental structure and function have been observed, little is understood about their molecular underpinnings. Here, we present a mega-analysis of 14 publicly available placenta DNA methylation (DNAm) microarray datasets to identify individual CpGs and regions associated with fetal sex. In the discovery dataset of placentas from full term pregnancies (N = 532 samples), 5212 CpGs met genome-wide significance (p p-value = 7.37E−14), chemokine activity (FDR p-value = 1.56E−2), and eosinophil migration (FDR p-value = 1.83E−2). Nine differentially methylated regions were identified (fwerArea ZNF300 that showed consistent differential DNAm in samples from earlier timepoints in pregnancy and appeared to be driven predominately by effects in the trophoblast cell type. We describe the largest study of fetal sex differences in placenta DNAm performed to date, revealing genes and pathways characterizing sex-specific placenta function and health outcomes later in life. |
| Databáze: | OpenAIRE |
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