Psoriasis vulgaris and familial cancer risk- a population-based study
| Autor: | Romuald Maleszka, A. Mirecka, Joanna Wiśniewska, Lidia Krysztoforska, Zygmunt Adamski, Magdalena Boer, Jan Lubinski, Ewa Soczawa, Katarzyna Paszkowska-Szczur, Tadeusz Dębniak, Monika Różewicka-Czabańska |
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| Rok vydání: | 2013 |
| Předmět: |
Oncology
medicine.medical_specialty Population Population stratification Bioinformatics 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Internal medicine Psoriasis Medicine education Genetics (clinical) Psoriasis vulgaris education.field_of_study business.industry Research Cancer medicine.disease Familial cancer risk Human genetics 3. Good health Lymphoma Population based study 030220 oncology & carcinogenesis Familial Cancer business |
| Zdroj: | Hereditary Cancer in Clinical Practice |
| ISSN: | 1897-4287 |
| DOI: | 10.1186/1897-4287-11-6 |
| Popis: | Background Follow-up studies of psoriasis patients indicate an increased risk in the occurrence of malignancies at different sites of origin. Population stratification and/or complicated interpretation of evidence on the risk of cancer (due to the small number of patients included in most series) lead to inconsistent data. Herein we investigated the risk of occurrence of malignancies at different sites of origin in a series of 517 psoriasis patients and their 1st degree relatives. Methods We evaluated the tumour spectrum as well as the age of the patient at diagnosis of cancers in psoriasis families along with the observed and expected frequencies of malignancies. The distribution of 17 common mutations/polymorphisms in 10 known cancer susceptibility genes among psoriasis patients and 517 matched healthy controls were examined. No such study has been published to date. Results The statistical comparison of the observed and expected frequencies of cancers revealed a higher than expected occurrence of Hodgkin’s lymphoma among males in psoriasis families when compared to the general population (OR=1.8, 95%CI 1.6-2.1, p=0.002). There was a non-significant tendency towards a younger age of onset and overrepresentation of laryngeal cancer and leukaemia in psoriasis families. We found no major differences in the distribution of cancer susceptibility mutations among our cases and the healthy controls. Conclusions The results of our study suggest an increased risk of Hodgkin’s lymphoma for male members of psoriasis families. Further studies are needed to confirm the findings and to evaluate whether or not the application of cancer surveillance protocols for Hodgkin’s lymphoma, leukaemia and laryngeal cancer are justified in these families. |
| Databáze: | OpenAIRE |
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