Effects of hyaluronan on periosteal grafts for large full-thickness defects in rabbit articular cartilage
| Autor: | Hideshige Moriya, Akira Katsumi, Yoshitada Harada, Masahiro Ishima, Yuuichi Wada, Izumi Kanisawa |
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| Rok vydání: | 1999 |
| Předmět: |
musculoskeletal diseases
Chondropathy Cartilage Articular Male medicine.medical_specialty medicine.medical_treatment Transplantation Autologous chemistry.chemical_compound Adjuvants Immunologic Periosteum Hyaluronic acid medicine Animals Orthopedics and Sports Medicine Hyaluronic Acid Saline Lagomorpha biology business.industry Histology Anatomy musculoskeletal system Chondrogenesis medicine.disease biology.organism_classification Surgery Hindlimb medicine.anatomical_structure chemistry Orthopedic surgery Rabbits business |
| Zdroj: | Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association. 4(2) |
| ISSN: | 0949-2658 |
| Popis: | We studied the effects of hyaluronan (HA) on chondrogenesis in periosteal grafts in rabbit knees to elucidate the effects of this agent in the repair of articular cartilage. Large full-thickness defects of the articular cartilage were created in the anteromedial part of the femoral articular surface of bilateral knee joints. Periosteal grafts were then harvested and sutured onto the defects. HA was injected in the right knee immediately after the operation and then once a week for 4 weeks (HA group). The same volume of saline was injected in the left knee in the control group. The animals were killed 2, 5, 8, and 12 weeks after the operation. Macroscopic and histological findings of the regenerated tissue were evaluated with a semiquantitative histological grading system. The total histological scores of the HA group were better than those in the control group at each time examination point. At 12 weeks, in particular, the scores for surface regularity and integration to adjacent articular cartilage were significantly better in the HA group than in the control group (P < 0.05). No significant differences were observed between the two groups in regard to the area healed (%). HA may have beneficial effects on the repair of large full-thickness defects of the articular cartilage with autologous periosteal grafts. |
| Databáze: | OpenAIRE |
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