System design and development of a robotic device for automated venipuncture and diagnostic blood cell analysis
| Autor: | Alex Gorshkov, Alvin I. Chen, Martin L. Yarmush, Max L. Balter, Alex Fromholtz, Tim Maguire |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Hematology Venipuncture Computer science Medical procedure Phlebotomy Article Venous access 03 medical and health sciences Blood draw 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis Internal medicine Blood cell analysis medicine Systems design Blood testing Blood vessel Biomedical engineering |
| Zdroj: | IROS |
| DOI: | 10.1109/iros.2016.7759102 |
| Popis: | Diagnostic blood testing is the most prevalent medical procedure performed in the world and forms the cornerstone of modern health care delivery. Yet blood tests are still predominantly carried out in centralized labs using large-volume samples acquired by manual venipuncture, and no end-to-end solution from blood draw to sample analysis exists today. Our group is developing a platform device that merges robotic phlebotomy with automated diagnostics to rapidly deliver patient information at the site of the blood draw. The system couples an image-guided venipuncture robot, designed to address the challenges of routine venous access, with a centrifuge-based blood analyzer to obtain quantitative measurements of hematology. In this paper, we first present the system design and architecture of the integrated device. We then perform a series of in vitro experiments to evaluate the cannulation accuracy of the system on blood vessel phantoms. Next, we assess the effects of vessel diameter, needle gauge, flow rate, and viscosity on the rate of sample collection. Finally, we demonstrate proof-of-concept of a white cell assay on the blood analyzer using in vitro human samples spiked with fluorescently labeled microbeads. |
| Databáze: | OpenAIRE |
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