Telomerase activity and survival of late-stage South African esophageal carcinoma patients
| Autor: | G. H. J. Pretorius, S. J. A. Smit, W. M. J. Van Den Heever |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Oncology
Adult Male Telomerase medicine.medical_specialty Esophageal Neoplasms Biopsy Population South Africa Esophagus Internal medicine Carcinoma Medicine Humans education Aged Aged 80 and over education.field_of_study Mucous Membrane business.industry Incidence (epidemiology) Gastroenterology Cancer General Medicine Middle Aged medicine.disease Prognosis Survival Analysis Log-rank test medicine.anatomical_structure Carcinoma Squamous Cell Field cancerization Female business |
| Zdroj: | Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus. 17(3) |
| ISSN: | 1120-8694 |
| Popis: | SUMMARY. Squamous cell carcinoma of the esophagus is a cancer with a high incidence in South Africa. We have investigated the prognostic value of telomerase activity in tumors as well as nearby normal tissue. Biopsies from 98 patients (71 men and 27 women) were analyzed using an adaptation of the TRAP assay. We found all tumor biopsies to have moderate to high telomerase activity, while one third of biopsies from normal mucosa were negative. The telomerase activity level of the tumors had no prognostic value (P = 0.95) as determined by the log rank test. A P-value of 0.02 was found when the telomerase-negative and moderately positive normal biopsies were grouped together and compared to those with high activity. Our results show that telomerase activity of normal mucosa in the vicinity of the tumor can identify a population of patients with significantly worse prognosis, even in late stage patients. |
| Databáze: | OpenAIRE |
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