Diffusion-Weighted Magnetic Resonance Imaging in Patients with Prostate Cancer Treated with Radiotherapy

Autor: Paola Rabasco, Vittorio Simeon, Antonella Lotumolo, Giuseppe Guglielmi, Luciana Rago, Aldo Cammarota, Luca Macarini, Pietro A. Mastrangelo, Antonio Villonio, Rocchina Caivano, Matilde Gioioso, Valeria Panebianco, Giancarlo Iannelli, Flavio Barchetti
Přispěvatelé: Iannelli, Giancarlo, Caivano, Rocchina, Rago, Luciana, Simeon, Vittorio, Lotumolo, Antonella, Rabasco, Paola, Villonio, Antonio, Gioioso, Matilde, Mastrangelo, Pietro, Barchetti, Flavio, Panebianco, Valeria, Macarini, Luca, Guglielmi, Giuseppe, Cammarota, Aldo
Rok vydání: 2015
Předmět:
Male
Cancer Research
medicine.medical_specialty
medicine.medical_treatment
Adenocarcinoma
030218 nuclear medicine & medical imaging
03 medical and health sciences
Prostate cancer
Magnetic resonance imaging
0302 clinical medicine
Diffusion-weighed imaging
Biomarkers
Tumor
medicine
Humans
Effective diffusion coefficient
Prospective Studies
Prospective cohort study
Aged
Aged
80 and over
medicine.diagnostic_test
business.industry
Prostatic Neoplasms
Reproducibility of Results
General Medicine
Prostate-Specific Antigen
medicine.disease
Diffusion-Weighted Magnetic Resonance Imaging
Radiation therapy
Prostate-specific antigen
apparent diffusion coefficient
diffusion-weighed imaging
magnetic resonance imaging
prostate cancer
response to therapy
adenocarcinoma
aged
aged
80 and over
biomarkers
tumor
feasibility studies
humans
male
neoplasm grading
prospective studies
prostate-specific antigen
prostatic neoplasms
reproducibility of results
sample size
treatment outcome
diffusion magnetic resonance imaging
Diffusion Magnetic Resonance Imaging
Treatment Outcome
Apparent diffusion coefficient
Oncology
Sample Size
030220 oncology & carcinogenesis
Feasibility Studies
Radiology
Response to therapy
Neoplasm Grading
business
Zdroj: Tumori Journal. 102:71-76
ISSN: 2038-2529
0300-8916
DOI: 10.5301/tj.5000415
Popis: Aims To evaluate the utility of a multiparametric 3T magnetic resonance imaging (MRI) study using diffusion-weighted images (DWI) for the assessment of prostate cancer before and after radiotherapy (RT). Methods A total of 34 patients, who received a histologic diagnosis of prostate adenocarcinoma, underwent MRI examination before and after local RT for the assessment of response to treatment. Apparent diffusion coefficient (ADC) values were calculated and compared. Results Before RT, DWI shows pathologic restriction of signal, while after RT pathologic restriction of signal was reduced or disappeared. The ADC values were significantly increased after therapy (pConclusions The use of DWI with ADC measurements may be an imaging biomarker in the assessment of prostate cancer.
Databáze: OpenAIRE
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