Regioselective Synthesis of Pyrazolo[4,5-g]pyrido[1,2-a]benzimidazoles: Cytotoxic Derivatives of Pyrido[1,2-a]benzimidazolic Ring System
| Autor: | Olivier Chavignon, Jean-Claude Teulade, Marianne Dupuy, Jean-Pierre Chapat, Yves Blache, Frederic Pingiet |
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| Rok vydání: | 1998 |
| Předmět: |
Antibiotics
Antineoplastic Magnetic Resonance Spectroscopy Stereochemistry Regioselectivity Antineoplastic Agents HL-60 Cells General Chemistry General Medicine Pyrazole Chemical synthesis In vitro Multiple drug resistance chemistry.chemical_compound chemistry Doxorubicin Cell culture Drug Discovery Tumor Cells Cultured medicine Humans Benzimidazoles K562 Cells Cytotoxicity medicine.drug |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 46:1820-1823 |
| ISSN: | 1347-5223 0009-2363 |
| Popis: | N-1 and N-2 substituted pyrazolo[4, 5-g]pyrido[1, 2-a]benzimidazoles were prepared regioselectively, and cytotoxicities evaluated in vitro against K562 and HL60 cells. All compounds displayed weaker activity than doxorubicin against sensitive lines, but showed the same activity against resistant cell lines (multidrug resistance +, (MDR+); K562R and HL60R) indicating no resistance phenomena. |
| Databáze: | OpenAIRE |
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