The Multifaceted Role of Th1, Th9, and Th17 Cells in Immune Checkpoint Inhibition Therapy
| Autor: | Jongdae Lee, Beatriz Lozano-Ruiz, Fengyuan Mandy Yang, Dengxia Denise Fan, Liya Shen, Jose M. González-Navajas |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
T cell Immunology Review Th1 Immune system Lymphocytes Tumor-Infiltrating Neoplasms PD-1 medicine Tumor Microenvironment Immunology and Allergy Cytotoxic T cell Animals Humans Th9 Immune Checkpoint Inhibitors biology business.industry Cancer Th1 Cells medicine.disease Immune checkpoint medicine.anatomical_structure Phenotype Treatment Outcome CTLA-4 T helper (Th) cell Cancer research biology.protein Th17 Cells immune checkpoint inhibition cancer therapy Th17 Antibody lcsh:RC581-607 business CD8 |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Vol 12 (2021) |
| ISSN: | 1664-3224 |
| Popis: | During the last decade, immune checkpoint inhibition (ICI) has become a pillar of cancer therapy. Antibodies targeting CTLA-4 or PD-1/PD-L1 have been approved in several malignancies, with thousands of clinical trials currently underway. While the majority of cancer immunotherapies have traditionally focused on enhancing cytotoxic responses by CD8+ or NK cells, there are clear evidences that CD4+ T cell responses can modulate the immune response against tumors and influence the efficacy of ICI therapy. CD4+ T cells can differentiate into several subsets of helper T cells (Th) or regulatory T cells (Treg), with a wide range of effector and/or regulatory functions. Importantly, different Th subsets may have different and sometimes contrasting roles in the clinical response to ICI therapy, which in addition may vary depending on the organ and tumor niche. In this review, we discuss recent evidence that highlights how ICI therapy impacts Th1, Th9, and Th17 cells and vice versa. These data might be important designing better interventions that unleash the full potential of immune response against cancer. |
| Databáze: | OpenAIRE |
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