The Role of Inflammatory Cytokines in Creating T Cell Exhaustion in Cancer
| Autor: | Mahmoud Rafieian-Kopaei, Mahdi Ghatrehsamani, Mojtaba Shohan, Milad Sabzevary-Ghahfarokhi, Hedayatollah Shirzad |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cancer Research Cell signaling T cell medicine.disease_cause Lymphocyte Activation Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine T-Lymphocyte Subsets Neoplasms Tumor Microenvironment Medicine Humans Radiology Nuclear Medicine and imaging Pharmacology Tumor microenvironment business.industry Effector Cell Differentiation General Medicine T lymphocyte 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Cancer cell Cancer research Cytokines business Carcinogenesis |
| Zdroj: | Cancer biotherapyradiopharmaceuticals. 33(7) |
| ISSN: | 1557-8852 |
| Popis: | Secreted inflammatory cytokines are considered as critical mediators in the tumor microenvironment. Cancer cells play a significant role in the differentiation of effector T cells to exhausted T cells through mediator production. Effector T cells that undergo tumor microenvironment become terminally differentiated into exhausted T cells. These changes create an opportunity for tumorigenesis and invasion of cancer cells. Despite having some characteristics of effector T cells, the exhausted T cells lose their antitumor properties. In this article, the phenotypes and function of exhausted T cells were reviewed and the expression pattern of inflammatory cytokines in tumor tissues and peripheral blood of cancer patients were described. Additionally, the effects of inflammatory cytokines on intracellular factors and signals of T lymphocyte cells were explained. In conclusion, the authors referred to probable approaches that could be used to improve the antitumor activity of T cells and intervention into T cell exhaustion. |
| Databáze: | OpenAIRE |
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