Observed versus predicted hospital mortality in general wards patients assisted by a medical emergency team

Autor: Alberto Zangrillo, Giovanni Landoni, Giacomo Monti, Pasin Laura, Stefano Turi, Sergio Colombo, Paolo Silvani, Valentina Paola Plumari, Luca Cabrini
Přispěvatelé: Cabrini, L, Monti, G, Plumari, Vp, Landoni, Giovanni, Turi, S, Laura, P, Silvani, P, Colombo, S, Zangrillo, Alberto
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: Scopus-Elsevier
Signa vitae : journal for intesive care and emergency medicine
Volume 7
Issue 1
ISSN: 1334-5605
1845-206X
Popis: "Introduction. Acute renal failure and fluid retention are common problems in pediatric patients after cardiac surgery. Furosemide, a loop diuretic drug, is frequently administered to increase urinary output. The aim of the present study was to compare efficacy and complications of continuous infusion of furosemide vs bolus injection among pediatric patients after cardiac surgery. Methods. A systematic review and meta-analysis was performed in compliance with The Cochrane Collaboration and the Quality of Reporting of Meta-Analysis (QUORUM) guidelines. The following inclusion criteria were employed for potentially relevant studies: a) random treatment allocation, b) comparison of furosemide bolus vs continuous infusion, c) surgical or intensive care pediatric patients. Non-parallel design randomized trials (e.g. cross-over), duplicate publications and non-human experimental studies were excluded. Results. Up to August 2008, only three studies were found, with 92 patients randomized (50 to continuous infusion and 42 to bolus treatment). Overall analysis showed that continuous infusion and bolus administration were equally effective in achieving the predefined urinary output, and were associated with a similar amount of administered furosemide (WMD=- 1.71 mg/kg/day [-5.20; +1.78], p for effect=0.34, p for heterogeneity
Databáze: OpenAIRE