Photodynamic Therapy Combined with Antibiotics or Antifungals against Microorganisms That Cause Skin and Soft Tissue Infections: A Planktonic and Biofilm Approach to Overcome Resistances
Autor: | Yolanda Gilaberte, Antonio Rezusta, Sofía Ballesta, Vanesa Pérez-Laguna, Isabel García-Luque |
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Přispěvatelé: | Universidad de Sevilla. Departamento de Microbiología |
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
medicine.drug_class
photoinactivation medicine.medical_treatment Microorganism 030303 biophysics Antibiotics Pharmaceutical Science Photodynamic therapy antimicrobial agents Review Microbiology resistance 03 medical and health sciences Antibiotic resistance Pharmacy and materia medica Drug Discovery MDR medicine 0303 health sciences biology 030306 microbiology business.industry SSTI Biofilm biology.organism_classification Antimicrobial In vitro RS1-441 Molecular Medicine Medicine business Bacteria |
Zdroj: | Zaguán. Repositorio Digital de la Universidad de Zaragoza instname idUS. Depósito de Investigación de la Universidad de Sevilla Pharmaceuticals, Vol 14, Iss 603, p 603 (2021) Pharmaceuticals |
Popis: | The present review covers combination approaches of antimicrobial photodynamic therapy (aPDT) plus antibiotics or antifungals to attack bacteria and fungi in vitro (both planktonic and biofilm forms) focused on those microorganisms that cause infections in skin and soft tissues. The combination can prevent failure in the fight against these microorganisms: antimicrobial drugs can increase the susceptibility of microorganisms to aPDT and prevent the possibility of regrowth of those that were not inactivated during the irradiation; meanwhile, aPDT is effective regardless of the resistance pattern of the strain and their use does not contribute to the selection of antimicrobial resistance. Additive or synergistic antimicrobial effects in vitro are evaluated and the best combinations are presented. The use of combined treatment of aPDT with antimicrobials could help overcome the difficulty of fighting high level of resistance microorganisms and, as it is a multi-target approach, it could make the selection of resistant microorganisms more difficult. |
Databáze: | OpenAIRE |
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