Kallmann's Syndrome and Schizophrenia
| Autor: | Venetsanos Mavreas, George A. Vagenakis, Argyro Sgourou, Apostolos G. Vagenakis, Anthi Protonatariou, Charalabos Papageorgiou, Panayotis A. Dimopoulos, Neoklis A. Georgopoulos, Thomas Hyphantis |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Paranoid schizophrenia Psychosis medicine.medical_specialty Pediatrics Kallmann syndrome Hypothalamus Anosmia Olfaction Disorders 03 medical and health sciences 0302 clinical medicine MMPI Pituitary Gland Anterior Hyposmia Hypogonadotropic hypogonadism Surveys and Questionnaires Internal medicine medicine Humans 030212 general & internal medicine Hypogonadism Brain Kallmann Syndrome medicine.disease Magnetic Resonance Imaging Olfactory Bulb 030227 psychiatry Diagnostic and Statistical Manual of Mental Disorders Psychiatry and Mental health Endocrinology Schizophrenia Female Atrophy medicine.symptom Psychology Kallmann's syndrome |
| Zdroj: | The International Journal of Psychiatry in Medicine. 34:379-390 |
| ISSN: | 1541-3527 0091-2174 |
| DOI: | 10.2190/hxr5-dgrc-jcmq-0cbh |
| Popis: | Objective: Kallmann's Syndrome is a heritable disorder characterized by the association of hypogonadotropic hypogonadism and anosmia or hyposmia. A common pathogenesis for KS and schizophrenia had been proposed based on shared pathologies of these two disorders, although no such clinical associations have ever been reported. Method: We report a 35 year old man with schizophrenia and Kallmann's Syndrome. The patient presented with signs and symptoms of hypogonadism, severe hyposmia and normal endocrine functions of the anterior pituitary. Hyposmia has been attributed to the absence of the olfactory bulbs and tracts and atrophy of the olfactory gyri, but normal olfactory mucosa. The patient presented with paranoid schizophrenia with persecutory delusions, auditory hallucinations, thought disorder, depersonalization, and gradual but marked global deterioration. Results: Psychiatric evaluation revealed an entirely different psychopathological and personality profile between the patient and the six other Kallmann patients studied. Cycle sequencing analysis revealed a normal sequence of all 14 exons of the KAL gene. In conclusion, based on the presented case, Kallmann's Syndrome and schizophrenia represent a rare clinical association rather than a syndrome with a common pathogenesis, which if present should be confined to the olfactory dysfunction. |
| Databáze: | OpenAIRE |
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