The feasibility of repeated left ventricular ejection fraction analysis with sequential single-dose radionuclide ventriculography
| Autor: | Iwan C. C. van der Horst, René A. Tio, Rudi Dierckx, Pieter A. van der Vleuten, Dirk-Jan van Veldhuisen, Riemer H. J. A. Slart, Felix Zijlstra |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Pertechnetate Radionuclide ventriculography Sensitivity and Specificity chemistry.chemical_compound Ventricular Dysfunction Left Internal medicine Image Interpretation Computer-Assisted medicine Humans Radiology Nuclear Medicine and imaging Myocardial infarction Radionuclide Ventriculography Sodium Pertechnetate Tc 99m Reproducibility Ejection fraction business.industry Reproducibility of Results Stroke Volume General Medicine Stroke volume Middle Aged medicine.disease chemistry Heart failure Injections Intravenous Cardiology Feasibility Studies Female Radiopharmaceuticals Nuclear medicine business |
| Zdroj: | Nuclear medicine communications. 26(8) |
| ISSN: | 0143-3636 |
| Popis: | Repeated left ventricular ejection fraction (LVEF) analyses with sequential single-dose radionuclide ventriculography might be an interesting technique for monitoring the effect of positive inotropic interventions. The aim of the study was to assess the reproducibility of LVEF measurement with planar radionuclide ventriculography within 3 h, using a standard single dose of radioactive tracer.Sixteen patients underwent routine planar radionuclide ventriculography with a standard dose of 500 MBq of [Tc]pertechnetate and returned after 3 h for a repeat planar radionuclide ventriculography without administration of additional tracer.The average initial LVEF was 35.1+/-18.6%-point (range, 12%-point to 68%-point). The mean difference of the LVEF between the initial planar radionuclide ventriculography and the repeat planar radionuclide ventriculography was 2.8%+/-6.3% (range, -11.8% to 13.3%, P=NS). The correlation between both measurements was significant with a correlation coefficient of 0.995 (P0.01). Bland-Altman analysis revealed a mean LVEF difference of 0.94%-point between the baseline planar radionuclide ventriculography and the repeat planar radionuclide ventriculography (95% confidence interval: -2.7%-point to 4.5%-point). The visual wall motion assessment showed excellent reproducibility, with a kappa-statistic of 0.98.Repeated radionuclide ventriculography with a 3 h interval using a single standard dose of 500 MBq of [Tc]pertechnetate is highly reproducible and will be useful for monitoring the effect of positive inotropic interventions. |
| Databáze: | OpenAIRE |
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