Fischer 344 Rats Display Age-Related Memory Deficits in Trace Fear Conditioning
| Autor: | Edwin J. Barea-Rodriguez, James R. Dykes, Julissa S. Villarreal |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
Senescence Aging Analysis of Variance Memory Disorders Time Factors Memoria Central nervous system Age Factors Classical conditioning Hippocampus Fear Rats Inbred F344 Rats Immobilization Behavioral Neuroscience medicine.anatomical_structure Conditioning Psychological medicine Animals Conditioning Fear conditioning Association (psychology) Psychology Neuroscience |
| Zdroj: | Behavioral Neuroscience. 118:1166-1175 |
| ISSN: | 1939-0084 0735-7044 |
| DOI: | 10.1037/0735-7044.118.6.1166 |
| Popis: | A functional hippocampus is required for trace fear conditioning, which involves learning the association of a tone and shock that are separated over time. Young and aged rats received 10 trace conditioning trials. Twenty-four hours later, rats were tested for fear to the tone in a novel chamber by measuring freezing. The results showed significantly lower levels of freezing in aged rats as compared with young rats, which provides evidence of age-related memory impairments. Pseudorandom conditioning groups showed low levels of freezing, indicative of no associative memory. Age-related memory deficits were not found with delay conditioning, which suggests no age-related sensory-motor deficits. These data suggest that aging hinders the ability of the hippocampus to process information separated over time. |
| Databáze: | OpenAIRE |
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