Long-Term Small Molecule and Protein Elution from TiO2 Nanotubes
| Autor: | Craig A. Grimes, Thomas J LaTempa, Tejal A. Desai, Lily Peng, Adam D. Mendelsohn, Sorachon Yoriya |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Materials science
Paclitaxel Diffusion Kinetics Serum albumin Antineoplastic Agents Bioengineering Cell Line Mice Animals Organic chemistry Molecule General Materials Science Cell Proliferation Drug Implants Sirolimus Titanium Nanotubes biology Elution Mechanical Engineering Albumin Proteins Serum Albumin Bovine General Chemistry Condensed Matter Physics Small molecule Pharmaceutical Preparations Biophysics biology.protein Macromolecule |
| Zdroj: | Nano Letters. 9:1932-1936 |
| ISSN: | 1530-6992 1530-6984 |
| DOI: | 10.1021/nl9001052 |
| Popis: | In this study, TiO(2) nanotubes of various dimensions were used to elute albumin, a large protein molecule, as well as sirolimus and paclitaxel, common small molecule drugs. The nanotubes controlled small molecule diffusion for weeks and large molecule diffusion for a month. Drug eluted from the nanotubes was bioactive and decreased cell proliferation in vitro. Elution kinetics was most profoundly affected by tube height. This study demonstrates that TiO(2) nanotubes may be a promising candidate for a drug-eluting implant coating. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|