Flavone cirsimarin impairs cell proliferation, migration, and invasion in MCF-7 cells grown in 2D and 3D models

Autor:	Juliana Mara Serpeloni, Larissa Cristina Bastos de Oliveira, Andressa Fujiike, Katiuska Tuttis, Diego Luis Ribeiro, Marcos Bispo Pinheiro Camara, Claudia Quintino da Rocha, Ilce Mara de Syllos Cólus
Rok vydání:	2021
Předmět:	Cell Line Tumor Spheroids Cellular MCF-7 Cells Humans Apoptosis Breast Neoplasms Female General Medicine Glycosides Toxicology Flavones Cell Proliferation
Zdroj:	Toxicology in vitro : an international journal published in association with BIBRA. 83
ISSN:	1879-3177
Popis:	The present study investigates the mechanisms underlying the in vitro antitumoral activity of cirsimarin (CIR 10 to 320 μM), a flavone extracted from the aerial parts of Scoparia dulcis L., on MCF-7 cells cultured in 2D and multicellular tumor spheroids (3D). CIR (from 40 μM) decreased cell viability in the resazurin assay and colony formation in the 2D model. In the same way, in the 3D model, CIR (from 40 μM) induced cell death (triple staining assay) and decreased spheroid integrity after 16 days with no induction of intracellular reactive species (CM-H
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f4b43e590f0510a84bc7ff206e57bed https://pubmed.ncbi.nlm.nih.gov/35710092 Zobrazit plný text záznamu Full Text from ScienceDirect