Drug-Induced Reversal of Early Diabetic Microangiopathy
| Autor: | Carlos A. Velasco, Rafael A. Camerini-Davalos, J.M.B. Bloodworth, Marvin Glasser |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Urology Diabetic angiopathy Placebo Asymptomatic Basement Membrane Prediabetic State Internal medicine Diabetes mellitus Biopsy medicine Humans Glucose tolerance test medicine.diagnostic_test business.industry Muscles Microangiopathy General Medicine Glucose Tolerance Test Middle Aged medicine.disease Capillaries Sulfonylurea Compounds Endocrinology Female medicine.symptom business Diabetic Angiopathies Glipizide medicine.drug |
| Zdroj: | New England Journal of Medicine. 309:1551-1556 |
| ISSN: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejm198312223092505 |
| Popis: | We performed three oral glucose-tolerance tests and three muscle biopsies over a period of approximately three years in 41 asymptomatic patients with chemical diabetes. At base line, 13 (32 per cent) had an increased capillary basement-membrane width in muscle. Twenty-three patients received glipizide, a new oral hypoglycemic compound, and 18 received placebo. In the patients receiving placebo the mean width of the muscle capillary basement membrane increased from 135.9 +/- 9.0 nm (S.E.M.) to 169.3 +/- 9.5 nm (P = 0.01), but in those receiving glipizide the value decreased to a level no different from that in subjects without diabetes: from 152.9 +/- 2.9 to 127.5 +/- 5.1 nm (P = 0.01). These findings suggest that microangiopathy, as indicated by an increased capillary basement-membrane width in muscle, may be present in a considerable number of patients with asymptomatic diabetes and that the changes can be reversed by early drug treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|