Impaired ventilatory acclimatization to hypoxia in mice lacking the immediate early gene fos B
| Autor: | Mohammad T. Malik, Ying-Jie Peng, Nanduri R. Prabhakar, David D. Kline, Gautam Adhikary |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Genotype Physiology Acclimatization Hypoxic ventilatory response Biology Hypercapnia Mice Oxygen Consumption Internal medicine Tidal Volume medicine Animals Wakefulness Respiratory system Hypoxia Plethysmography Whole Body Mice Knockout Respiration General Neuroscience Wild type Hypoxia (medical) medicine.anatomical_structure Endocrinology Carotid body Blood Gas Analysis medicine.symptom Proto-Oncogene Proteins c-fos Immediate early gene |
| Zdroj: | Respiratory Physiology & Neurobiology. 145:23-31 |
| ISSN: | 1569-9048 |
| DOI: | 10.1016/j.resp.2004.08.009 |
| Popis: | Earlier studies on cell culture models suggested that immediate early genes (IEGs) play an important role in cellular adaptations to hypoxia. Whether IEGs are also necessary for hypoxic adaptations in intact animals is not known. In the present study we examined the potential importance of fos B, an IEG in ventilatory acclimatization to hypoxia. Experiments were performed on wild type and mutant mice lacking the fos B gene. Ventilation was monitored by whole body plethysmography in awake animals. Baseline ventilation under normoxia, and ventilatory response to acute hypoxia and hypercapnia were comparable between wild type and mutant mice. Hypobaric hypoxia (0.4 atm; 3 days) resulted in a significant elevation of baseline ventilation in wild type but not in mutant mice. Wild type mice exposed to hypobaric hypoxia manifested an enhanced hypoxic ventilatory response compared to pre-hypobaric hypoxia. In contrast, hypobaric hypoxia had no effect on the hypoxic ventilatory response in mutant mice. Hypercapnic ventilatory responses, however, were unaffected by hypobaric hypoxia in both groups of mice. These results suggest that the fos B, an immediate early gene, plays an important role in ventilatory acclimatization to hypoxia in mice. |
| Databáze: | OpenAIRE |
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