Association of birth mode of delivery with infant faecal microbiota, potential pathobionts, and short chain fatty acids: a longitudinal study over the first year of life
Autor: | Sara E. Benjamin-Neelon, Cathrine Hoyo, Noel T. Mueller, Moira K. Differding, Truls Østbye |
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Rok vydání: | 2021 |
Předmět: |
Adult
Clostridium perfringens Offspring medicine.medical_treatment Population Physiology Gut flora Article Feces Young Adult 03 medical and health sciences 0302 clinical medicine Pregnancy medicine Bacteroides Humans Caesarean section Longitudinal Studies Prospective Studies education Bifidobacterium Clostridium education.field_of_study 030219 obstetrics & reproductive medicine biology Cesarean Section Vaginal delivery business.industry Infant Newborn Infant Obstetrics and Gynecology Delivery Obstetric Fatty Acids Volatile biology.organism_classification Delivery mode Gastrointestinal Microbiome Butyrates Female business |
Zdroj: | BJOG |
ISSN: | 1471-0528 1470-0328 |
Popis: | OBJECTIVE Caesarean section (CS) interrupts mother-to-newborn microbial transfer at birth. Beyond the neonatal period, the impact of CS on offspring gut microbiota and their short-chain fatty acids (SCFAs) remains unclear. Here, we examine birth delivery mode (CS versus vaginal delivery) with the infant gut microbiota and faecal SCFAs measured 3 and 12 months after birth. DESIGN Longitudinal study. SETTING North Carolina. POPULATION In 2013-15, we enrolled pregnant women and followed up their offspring for 12 months. We asked a subset of participants, enrolled over a 3-month period, to provide faecal samples at the 3- and 12-month follow-up visits. METHODS AND MAIN OUTCOMES We sequenced the 16S rRNA V4 region with Illumina MiSeq and quantified SCFA concentrations using gas chromatography. We examined delivery mode with differential abundance of microbiota amplicon sequence variants (ASVs) using beta-binomial regression and faecal SCFAs using linear regression. We adjusted models for confounders. RESULTS Of the 70 infants in our sample, 25 (36%) were delivered by CS. Compared with vaginal delivery, CS was associated with differential abundance of 14 infant bacterial ASVs at 3 months and 13 ASVs at 12 months (all FDR P < 0.05). Of note, CS infants had a higher abundance of the potential pathobionts Clostridium neonatale (P = 0.04) and Clostridium perfringens (P = 0.04) and a lower abundance of potentially beneficial Bifidobacterium and Bacteroides spp. (both P < 0.05) at 3 months. Other ASVs were differentially abundant at 12 months. Infants delivered by CS also had higher faecal butyrate concentration at 3 months (P |
Databáze: | OpenAIRE |
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