Topical Treatment with 22-oxacalcitriol (OCT), a New Vitamin D Analogue, Caused Severe Hypercalcemia with Exacerbation of Chronic Renal Failure in a Psoriatic Patient with Diabetic Nephropathy; A Case Report and Analysis of the Potential for Hypercalcemia
| Autor: | Daigaku Uchida, Sawako Ohigashi, Mayumi Higurashi, Ichiro Tatsuno, Saori Hoshimoto, Natoake Hashimoto, Yasushi Saito, Naoto Seki |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Exacerbation medicine.medical_treatment Renal function Diabetic nephropathy Calcitriol Psoriasis Internal Medicine medicine Vitamin D and neurology Humans Diabetic Nephropathies Chemotherapy business.industry Metabolic disorder General Medicine Middle Aged medicine.disease Dermatology Surgery Hypercalcemia Kidney Failure Chronic Dermatologic Agents business Kidney disease |
| Zdroj: | Internal Medicine. 42:1202-1205 |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.42.1202 |
| Popis: | Vitamin D has been used for topical treatment of psoriasis, and 22-oxacalcitriol (OCT), shown to be less calcemic, was developed for the topical treatment of psoriasis in Japan. Recently, we treated a psoriatic patient with diabetic nephropathy who developed severe hypercalcemia with exacerbation of chronic renal failure by the use of topical OCT. Analysis of the reported cases demonstrated that both the severity of psoriasis and renal dysfunction are critical factors in the induction of hypercalcemia in the topical treatment of psoriasis. Therefore, we must pay attention to the severity of psoriasis, especially when complicated by renal function impairment. Regular monitoring of Ca and renal function is essential to avoid life-threatening hypercalcemia from the topical treatment with vitamin D analogues. |
| Databáze: | OpenAIRE |
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