Clotrimazole as a Cancer Drug: A Short Review
| Autor: | White S, Stailey C, Kadavakollu S, Kunapareddy Cs |
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| Rok vydání: | 2016 |
| Předmět: |
Drug
Programmed cell death Hexokinase Calmodulin biology Clotrimazole business.industry media_common.quotation_subject Cancer drugs Pharmacology Article chemistry.chemical_compound chemistry Mechanism of action Cancer cell medicine biology.protein medicine.symptom business medicine.drug media_common |
| Zdroj: | Medicinal chemistry. 4(11) |
| ISSN: | 2161-0444 |
| Popis: | Although clotrimazole was first used against fungal infections, a body of research was later developed indicating that this drug has anticancer properties as well. The mechanism of action is based on the inhibition of mitochondrial-bound glycolytic enzymes and calmodulin, which starves cancer cells of energy. Clotrimazole and its derivatives have been shown to decrease rates of cancer cell proliferation, induce G1 phase arrest, and promote pro-apoptotic factors, which lead to cell death. |
| Databáze: | OpenAIRE |
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