Effects of Acute Alcohol Intoxication on Empathic Neural Responses for Pain
| Autor: | Zhaoxin Wang, Yilai Pei, Zhuoya Cui, Mingxia Fan, Yang Hu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
PPI
trait empathy media_common.quotation_subject pain empathy Population Empathy Placebo 050105 experimental psychology lcsh:RC321-571 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Alcohol intoxication Medicine 0501 psychology and cognitive sciences alcohol intoxication education lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Biological Psychiatry Anterior cingulate cortex Original Research media_common education.field_of_study business.industry fMRI 05 social sciences Attentional control medicine.disease Psychiatry and Mental health Neuropsychology and Physiological Psychology medicine.anatomical_structure Neurology business Insula 030217 neurology & neurosurgery Pain empathy Neuroscience Clinical psychology |
| Zdroj: | Frontiers in Human Neuroscience, Vol 11 (2018) Frontiers in Human Neuroscience |
| ISSN: | 1662-5161 |
| Popis: | The questions whether and how empathy for pain can be modulated by acute alcohol intoxication in the non-dependent population remain unanswered. To address these questions, a double-blind, placebo-controlled, within-subject study design was adopted in this study, in which healthy social drinkers were asked to complete a pain-judgment task using pictures depicting others' body parts in painful or non-painful situations during fMRI scanning, either under the influence of alcohol intoxication or placebo conditions. Empathic neural activity for pain was reduced by alcohol intoxication only in the dorsal anterior cingulate cortex (dACC). More interestingly, we observed that empathic neural activity for pain in the right anterior insula (rAI) was significantly correlated with trait empathy only after alcohol intoxication, along with impaired functional connectivity between the rAI and the fronto-parietal attention network. Our results reveal that alcohol intoxication not only inhibits empathic neural responses for pain but also leads to trait empathy inflation, possibly via impaired top-down attentional control. These findings help to explain the neural mechanism underlying alcohol-related social problems. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|