Cognitively Based Compassion Training for HIV Immune Nonresponders—An Attention-Placebo Randomized Controlled Trial

Autor: Titanji, Boghuma K., Tejani, Mehul, Farber, Eugene W., Mehta, C. Christina, Pace, Thaddeus W., Meagley, Kathryn, Gavegnano, Christina, Harrison, Timothy, Kokubun, Caroline W., Negi, Satya Dev, Schinazi, Raymond F., Marconi, Vincent C.
Rok vydání: 2022
Předmět:
Zdroj: J Acquir Immune Defic Syndr
ISSN: 1525-4135
DOI: 10.1097/qai.0000000000002874
Popis: OBJECTIVE: Chronic inflammation is associated with increased morbidity and mortality for people with HIV (PWH). Psychological stress is an important contributor to this chronic inflammation. We hypothesized that a Cognitively-Based Compassion Training (CBCT) approach could reduce inflammation and psychological stress in immune non-responder PWH. DESIGN: An attention-placebo randomized controlled trial design to evaluate the acceptability of CBCT among PWH and its effects on key aspects of stress and immune function compared to an active-attention control group (NCT02395289). METHODS: This study was conducted at an HIV clinic in Atlanta, Georgia. Eligible individuals determined by (1) adherence to ART for at least a year, (2) virologic suppression and (3) stable CD4(+) T-cell counts
Databáze: OpenAIRE