Composite lymphoid neoplasm of B-cell and T-cell origins: a pathologic study of 14 cases
| Autor: | Catherine Rehder, Russell K. Brynes, Charles Blake Hutchinson, Siby Sebastian, Qin Huang, Alun R. Wang, Jun Wang, Deepti M. Reddi, Endi Wang, Paulie Papavassiliou, Imran Siddiqi, Abner Louissaint, Qiang Wei |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Pathology medicine.medical_specialty Lymphoma B-Cell Lineage (genetic) Adolescent T cell Population Biology Lymphoma T-Cell Virus Pathology and Forensic Medicine Neoplasms Multiple Primary Dogs Leukemia B-Cell medicine Animals Humans education In Situ Hybridization B cell Aged Retrospective Studies education.field_of_study Middle Aged Amplicon Flow Cytometry medicine.disease Immunohistochemistry Lymphoma medicine.anatomical_structure Female |
| Zdroj: | Human Pathology. 45:768-784 |
| ISSN: | 0046-8177 |
| DOI: | 10.1016/j.humpath.2013.11.008 |
| Popis: | We retrospectively analyzed 14 composite lymphoma/lymphoid neoplasms (CL) of B-cell/T-cell origins. These consisted of a spectrum of T-cell neoplasms in combination with different B-cell lymphomas/leukemias, with peripheral T-cell lymphoma and diffuse large B-cell lymphoma encountered most frequently for each respective neoplastic lineage. Histopathologic evaluation demonstrated 6 patterns of neoplastic distribution, including zone, inverted zone, diffuse mixed, regional/nodular mixed, compartmental, and segmental distributions. Four of 9 cases studied were positive for Epstein-Barr virus, all with a mixed pattern, suggesting that this pattern may predict an Epstein-Barr virus association. None of 14 cases was considered CL at the initial histologic evaluation. Only 6 (46.2%) of 13 cases had coexisting B-cell/T-cell neoplasms highlighted by immunohistochemistry, and the other 7 (53.8%) cases had 1 or both of the neoplastic components hidden. Flow cytometry detected both neoplastic lineages in 4 (44%) but failed to detect a clonal B-cell population in 4 (44%) and missed neoplastic T cells in 1 (11.1%) of 9 cases. Molecular testing detected clonal rearrangement of IGH/K gene in 11 (84.6%) of 13 cases, and clonal rearrangement of the TCRG/B gene in 13 (92.9%) of 14 cases, including 8 with identical amplicons detected in separate samples. CLs of B-cell/T-cell origin are heterogeneous in subtype combination and topographic pattern, often with one of the components histologically occult. A multidisciplinary approach is emphasized to establish a definitive diagnosis in these challenging cases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect