The effect of aldosterone on adiposity - The role of glucose absorption in the small intestine
| Autor: | Hiroshi Sato, Hidekazu Shirai, Akiyo Sekimoto, Taeko Uchida, Sadayoshi Ito, Emiko Sato, Yuji Oe, Nobuyuki Takahashi |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Aldosterone synthase Male medicine.medical_specialty Biophysics Body weight Biochemistry Glucose absorption Jejunum 03 medical and health sciences chemistry.chemical_compound Feces 0302 clinical medicine Sodium-Glucose Transporter 1 Internal medicine Renin–angiotensin system Intestine Small medicine Animals Cytochrome P-450 CYP11B2 Epithelial Sodium Channels Molecular Biology Aldosterone Adiposity Mice Knockout biology Chemistry Body Weight Sodium Cell Biology Small intestine Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Endocrinology Glucose Intestinal Absorption 030220 oncology & carcinogenesis biology.protein Body Composition |
| Zdroj: | Biochemical and biophysical research communications. 531(4) |
| ISSN: | 1090-2104 |
| Popis: | We have previously demonstrated that manipulation of the renin angiotensin system (RAS) has large effects on digestive efficiency. However, the effects of aldosterone on body weight, adiposity, and glucose absorption in the intestine remains unknown. We here demonstrated that lack of aldosterone synthase (ASKO) in mice did not affect adiposity. In contrast, mice administered with aldosterone were resistant to diet-induced obesity. This is due to gastrointestinal loss of dietary glucose. As expected, ASKO mice had increased glucose absorption, whereas mice administered with aldosterone had reduced glucose absorption in the small intestine. Furthermore, the level of protein expression of sodium glucose transporter 1 (SGLT1) in the mucosa of the jejunum was higher in ASKO mice, and lower in mice administered with aldosterone than control mice. Our findings indicate that aldosterone plays an important role on SGLT-1-mediated glucose absorption in the small intestine. |
| Databáze: | OpenAIRE |
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