Coronary flow reserve is impaired in patients with adult growth hormone (GH) deficiency
| Autor: | Fatma Sen, Huseyin Oflaz, Mustafa Demirturk, Faruk Kutluturk, Arif Oguzhan Cimen, Nese Ozbey, Erdem Kasikcioglu, Semra Korkmaz, Imran Onur, Ali Elitok, Burak Pamukcu |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Endothelium Endocrinology Diabetes and Metabolism medicine.medical_treatment Doppler echocardiography Hypopituitarism Growth hormone deficiency Endocrinology Insulin resistance Internal medicine Coronary Circulation medicine Humans Endothelial dysfunction Insulin-Like Growth Factor I medicine.diagnostic_test business.industry Insulin Microcirculation Coronary flow reserve Signal Processing Computer-Assisted Middle Aged medicine.disease Coronary Vessels Echocardiography Doppler medicine.anatomical_structure Cross-Sectional Studies Case-Control Studies Growth Hormone Female Endothelium Vascular business Lipid profile Tunica Media Blood Flow Velocity |
| Zdroj: | Clinical endocrinology. 66(4) |
| ISSN: | 0300-0664 |
| Popis: | Summary Objective Relationship between adult growth hormone deficiency (AGHD) and increased cardiovascular disease risk is very well known in hypopituitary patients treated with conventional hormone replacement therapy other than growth hormone (GH) administration. Endothelial dysfunction, an early and reversible event in pathogenesis of atherosclerosis, is associated with increased vascular smooth muscle tone, arterial stiffening and intima-media thickness (IMT). Coronary flow reserve (CFR) measurement by transthoracic Doppler echocardiography (TTDE) reflects coronary microvascular and endothelial functions, as a cheaper and an easy screening test. We have used TTDE to evaluate endothelial function and coronary microvascular function in AGHD. Design Cross-sectional observational study. Patients A total of 10 GH-deficient adults on conventional replacement therapy other than GH (4 males, 6 females; mean age 37 ± 11 years) and 15 healthy subjects (7 males, 8 females; mean age 41 ± 11 years) were studied. Patients and controls were all nonsmokers, normotensive and nondiabetic. Measurements IGF-1, free T4, lipid profile, insulin, glucose, insulin resistance (IR), anthropometrical and physical parameters were recorded. CFR recordings and IMT measurements were performed using the Vivid 7 echocardiography device. Results IMT were significantly higher in patients than controls (0·70 + 0·19 mm and 0·53 + 0·13 mm, respectively; P = 0·02). CFR was significantly lower in patients than in controls (1·96 ± 0·35 and 2·62 ± 0·45, respectively; P |
| Databáze: | OpenAIRE |
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