A comparison of the effects of several antifungal imidazole derivatives and polyenes on Candida albicans: an ultrastructural study by scanning electron microscopy
| Autor: | Jouvert S, Madeleine Bastide, Bastide Jm |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Nystatin
Antifungal Agents Econazole Miconazole Stereochemistry Immunology Biology Applied Microbiology and Biotechnology Microbiology Piperazines chemistry.chemical_compound Isoconazole Cell Wall Amphotericin B Candida albicans Genetics medicine Imidazole Clotrimazole Molecular Biology Cell Membrane fungi Imidazoles General Medicine Polyene Ketoconazole chemistry Microscopy Electron Scanning medicine.drug |
| Zdroj: | Canadian Journal of Microbiology. 28:1119-1126 |
| ISSN: | 1480-3275 0008-4166 |
| DOI: | 10.1139/m82-166 |
| Popis: | The early events in the interaction of two polyene (amphotericin B and nystatin) and five imidazole (clotrimazole, ketoconazole, miconazole, isoconazole, and econazole) antimycotics used at fungicidal concentrations with the surface of Candida albicans were studied by scanning electron microscopic examination of treated intact young yeast cells, treated spheroplasts, and spheroplasts liberated from treated young yeast cells. In all cases, treatment lasted 2 h. The polyenes passed through the yeast cell wall and interacted with the cytoplasmic membrane causing the spheroplasts to lose their characteristic spheric form and to liberate their contents. Clotrimazole caused the formation of numerous circular openings in the cytoplasmic membrane, but only when the agent was used to treat spheroplasts directly. Ketoconazole, miconazole, isoconazole, and econazole interacted with the cell wall causing formation of convolutions and wrinkles. The three imidazole derivatives that are structurally closely related, miconazole, isoconazole, and econazole, inhibited the enzyme-catalyzed release of spheroplasts from young yeast cells. |
| Databáze: | OpenAIRE |
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