Dehydroepiandrosterone (DHEA) Sulfate Prevents Reduction in Tissue Vitamin E and Increased Lipid Peroxidation Due to Murine Retrovirus Infection of Aged Mice
| Autor: | Mohsen Araghi-Niknam, Ronald R. Watson, Mark Molitor, S. K. Ardestani, Cleamond D. Eskelson, Paula Inserra |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Aging
medicine.medical_specialty Antioxidant medicine.medical_treatment Phospholipid Dehydroepiandrosterone General Biochemistry Genetics and Molecular Biology Lipid peroxidation Mice chemistry.chemical_compound Dehydroepiandrosterone sulfate Retrovirus Murine Acquired Immunodeficiency Syndrome Internal medicine Murine leukemia virus medicine Animals Vitamin E Vitamin E Deficiency Vitamin A Phospholipids biology Dehydroepiandrosterone Sulfate Myocardium biology.organism_classification Mice Inbred C57BL Cholesterol Endocrinology Liver chemistry Female Lipid Peroxidation |
| Zdroj: | Experimental Biology and Medicine. 218:210-217 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-218-44288 |
| Popis: | Dietary effects of dehydroepiandrosterone sulfate (DHEAS) supplementa- tion on tissue antioxidants and lipids were investigated in retrovirus infected mice. DHEA is a powerful antioxidant and immunomodulator whose production declines with age. For this study, twenty-four female, 15-month-old C57BU6 mice were left uninfected while twenty-four were infected with LP-BM5 murine leukemia virus, caus- ing murine AIDS. The retroviral infection caused immune dysfunction and loss of hepatic and cardiac vitamins E and A, resulting in increased lipid peroxides. Treat- ment with DHEAS at 0.01 or 0.005% in drinking water for 10 weeks post-infection significantly (P c 0.05) lowered lipid peroxidation in both heart and liver tissues. Treatment with DHEAS also largely prevented loss of the antioxidants, such as vita- min E and A, and prevented loss of phospholipid in the hearts and livers of the old uninfected as well as infected mice. This study suggests that DHEAS supplementation reduces damage associated with elevated oxidation due to aging and retrovirus in- fection. (P.S.E.B.M. 1998, Vol 2181 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|