A simple alternative to prodrug: the hydrochloride salt monohydrate of the prostate anticancer drug abiraterone
Autor: | Patricia da Cruz Souza, Alzir A. Batista, Deborah V.A. de Aguiar, Rafael G. Silveira, Beatriz N. Cunha, Boniek G. Vaz, Javier Ellena, Felipe T. Martins, Juan C. Tenorio |
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Rok vydání: | 2019 |
Předmět: |
Active ingredient
010405 organic chemistry Chemistry Hydrochloride Organic Chemistry Supramolecular chemistry Abiraterone acetate Free base Protonation Prodrug 010402 general chemistry Crystal engineering 01 natural sciences Combinatorial chemistry 0104 chemical sciences Analytical Chemistry Inorganic Chemistry chemistry.chemical_compound Spectroscopy NEOPLASIAS DOS GENITAIS MASCULINOS |
Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
Popis: | Abiraterone acetate is a first choice prodrug to treat prostate cancer. New higher-solubility multicomponent crystal forms of the active compound abiraterone could substitute for the commonly used acetate prodrug. Here we prepare abiraterone hydrochloride monohydrate, which is the first multicomponent crystal form of this striking prostate anticancer agent. Its solid state characterization by single-crystal X-ray diffraction (SCXRD), infrared (IR) spectroscopy and thermogravimetry (TG) was performed. The only conformational difference in the molecular backbone common to the literature related crystal forms (abiraterone acetate and the free base abiraterone) and our salt resides in the 3-pyridil rotation upon protonation. If the neutral molecules found in the two literature structures are taken as references, this motif is rotated by almost exactly 180° in our protonated abiraterone. Crystal packing also follows the protonation pattern. While in both prodrug and free base there is formation of head-to-tail fashioned one-dimensional chains as the main supramolecular entities, hydrogen bonded sheets are the main supramolecular motifs of abiraterone hydrochloride monohydrate. In addition, the IR spectrum and the TG thermogram of the hydrochloride salt monohydrate are present with characteristics absorption bands and thermal events, being therefore useful as analytical data for control quality purposes of this promising active pharmaceutical ingredient. |
Databáze: | OpenAIRE |
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