| Autor: |
Leonard Oppenheimer, Thomas P. Capizzi, Hina. Mehta |
| Rok vydání: |
1983 |
| Předmět: |
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| Zdroj: |
Journal of Pharmaceutical Sciences. 72:995-999 |
| ISSN: |
0022-3549 |
| Popis: |
A method is provided for estimating the area under a response-time curve for an experimental situation where independent observations are made at each time point. The procedure utilizes least-squares spline functions and the jackknife technique to provide area estimates, standard errors, and a statistical test for intergroup comparisons. The method is based on an empirical model and provides a means of analysis when no prior model can be specified or if the incorrect specification of a model will produce invalid results. The method is illustrated using data from a study comparing the pharmacokinetic behavior of a fasciolicide in rats having either a young or old parasitic infestation. The results obtained are comparable with those generated by a model-dependent approach. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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