N‐Heterocyclic Carbene Catalyzed Ester Synthesis from Organic Halides through Incorporation of Oxygen Atoms from Air
| Autor: | Hui Tan, Ning Jiao, Jianzhong Liu, Zixi Yan, Jialiang Wei, Song Song, Shen-An Wang |
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| Rok vydání: | 2020 |
| Předmět: |
Reaction mechanism
010405 organic chemistry Atom (order theory) chemistry.chemical_element Halide General Medicine General Chemistry 010402 general chemistry Medicinal chemistry 01 natural sciences Oxygen Combinatorial chemistry Catalysis 0104 chemical sciences chemistry.chemical_compound Oxygen atom chemistry Molecular oxygen Carbene |
| Zdroj: | Angewandte Chemie International Edition. 60:2140-2144 |
| ISSN: | 1521-3773 1433-7851 |
| DOI: | 10.1002/anie.202011039 |
| Popis: | Oxygenation reactions with molecular oxygen (O2 ) as the oxygen source provides a green and straightforward strategy for the construction of O-containing compounds. Demonstrated here is a novel N-heterocyclic carbene (NHC) catalyzed oxidative transformation of simple and readily available organic halides into valuable esters through the incorporation of O-atoms from O2 . Mechanistic studies prove that the deoxy Breslow intermediate generated in situ is oxidized to a Breslow intermediate for further transformation by this oxidative protocol. This method broadens the field of NHC catalysis and promotes oxygenation reactions with O2 . |
| Databáze: | OpenAIRE |
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