Donor Outcomes After Liver Donation in Adult to Adult Living Donor Liver Transplantation
| Autor: | L.L.-C. Tsang, Chao-Long Chen, Hsin-You Ou, Tai-Yi Chen, Yu-Shun Tong, Yu Fan Cheng, Wei-Xiong Lim, Tung Liang Huang, Chih-Teng Yu, Hsien-Wen Hsu |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Bilirubin 030230 surgery Gastroenterology law.invention 03 medical and health sciences chemistry.chemical_compound Postoperative Complications 0302 clinical medicine Risk Factors law Statistical significance Internal medicine Living Donors Hepatectomy Humans Medicine Transplantation business.industry Significant difference Postoperative complication Middle Aged Intensive care unit Liver regeneration Liver Regeneration Liver Transplantation chemistry Donation Female 030211 gastroenterology & hepatology Surgery business Living donor liver transplantation |
| Zdroj: | Transplantation Proceedings. 50:2588-2592 |
| ISSN: | 0041-1345 |
| DOI: | 10.1016/j.transproceed.2018.04.006 |
| Popis: | This study aims to investigate postdonation outcomes of adult living donor liver transplantation donors and remnant liver regeneration in different graft types.A total of 236 adult living donor liver transplantation donors were classified into different groups: donors with 35% remnant liver volume (group A; n = 56) and donors with remnant liver volume ≥35% (group B, n = 180); left lobe grafts (LLG group; n = 98) including middle hepatic vein (MHV) and right lobe grafts (RLG group; n = 138) without MHV. The 98 LLG group donors were further classified into 2 subgroups based on hepatic venous drainage patterns: MHV-dominant (n = 20) and non-MHV-dominant (n = 78). The demographic data, postoperative laboratory data, complications, graft weight, remnant liver volume, remnant liver growth rate, and remnant liver regeneration rate (RLRR) after partial liver donation were analyzed.The postoperative aspartate aminotransferase, alanine aminotransferase, total bilirubin, intensive care unit stays, and hospitalization stays were higher in A and RLG group donors. All the donor complications in our series were minor complications. The postoperative complication rate was higher in the A and RLG group, but failed to reach statistical significance. There was no significant difference in RLRR between the RLG/LLG and A/B groups. However, the MHV-dominant group had significantly lower RLRR than the non-MHV-dominant group (P .05).Small remnant liver volume donors (35% remnant liver) have higher risks of developing postdonation minor complications. Left lobe liver donation in MHV-dominant donor candidates are a major concern. |
| Databáze: | OpenAIRE |
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