The advent of fear conditioning as an animal model of post-traumatic stress disorder: Learning from the past to shape the future of PTSD research
| Autor: | Maël Lemoine, Thomas C M Bienvenu, Bruno Aouizerate, Daniel Jercog, Cyril Dejean, Cyril Herry |
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| Přispěvatelé: | INSERM, Neurocentre Magendie, U1215, Physiopathologie de la Plasticité Neuronale, F-33000 Bordeaux, France, Nutrition et Neurobiologie intégrée (NutriNeuro), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
General Neuroscience Traumatic stress Translational research Vagueness Fear Variety (cybernetics) Stress Disorders Post-Traumatic Translational Research Biomedical 03 medical and health sciences Disease Models Animal 030104 developmental biology 0302 clinical medicine Conceptual approach Animal model Conditioning Psychological Animals [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Fear conditioning Association (psychology) Psychology 030217 neurology & neurosurgery Cognitive psychology |
| Zdroj: | Neuron Neuron, Elsevier, 2021, 109 (15), pp.2380-2397. ⟨10.1016/j.neuron.2021.05.017⟩ |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/j.neuron.2021.05.017⟩ |
| Popis: | Translational research on post-traumatic stress disorder (PTSD) has produced limited improvements in clinical practice. Fear conditioning (FC) is one of the dominant animal models of PTSD. In fact, FC is used in many different ways to model PTSD. The variety of FC-based models is ill defined, creating confusion and conceptual vagueness, which in turn impedes translation into the clinic. This article takes a historical and conceptual approach to provide a comprehensive picture of current research and help reorient the research focus. This work historically reviews the variety of models that have emerged from the initial association of PTSD with FC, highlighting conceptual pitfalls that have limited the translation of animal research into clinical advances. We then provide some guidance on how future translational research could benefit from conceptual and technological improvements to translate basic findings in patients. This objective will require transdisciplinary approaches and should involve physicians, engineers, philosophers, and neuroscientists. |
| Databáze: | OpenAIRE |
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