Synthesis and conformational analysis of novel 2',3'-didehydo-2',3'-dideoxy-4'-selenonucleosides
| Autor: | Won Jun Choi, Lak Shin Jeong, Yun Jung Ko, Long Xuan Zhao, Jung Ha Jun |
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| Rok vydání: | 2008 |
| Předmět: |
Olefin fiber
Dideoxynucleosides Stereochemistry Chemistry Anti-HIV Agents RNA-Directed DNA Polymerase Human immunodeficiency virus (HIV) General Medicine medicine.disease_cause Reverse transcriptase chemistry.chemical_compound Organoselenium Compounds medicine Nucleic Acid Conformation Reverse Transcriptase Inhibitors Thiocarbonate |
| Zdroj: | Nucleic acids symposium series (2004). (52) |
| ISSN: | 1746-8272 |
| Popis: | The structure of 2',3'-didehydro-2',3'-dideoxynucleosides (d4Ns) was applied to design the novel bioisosteric 4'-seleno-d4Ns as potential inhibitors of human immunodeficiency virus reverse transcriptase (HIV RT). Conversion of 2',3'-dihydroxyl groups of 4'-selenoribofuranosyl pyrimidines into the olefin was accomplished by treatment of cyclic 2',3'-thiocarbonate with 1,3-dimethyl-2-phenyl-1,3,2-diazaphospholidine. |
| Databáze: | OpenAIRE |
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