Journey of the iodide transporter NIS: from its molecular identification to its clinical role in cancer
| Autor: | Claudia A. Riedel, Nancy Carrasco, Orsolya Dohán, Antonio De la Vieja, Christopher S. Ginter |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Mammary gland Thyroid Gland Biochemistry Mammary Glands Animal Breast cancer Internal medicine medicine Animals Molecular Biology Thyroid cancer health care economics and organizations Symporters business.industry Thyroid disease Thyroid Membrane Proteins Cancer Transporter Genetic Therapy Neoplasms Experimental medicine.disease medicine.anatomical_structure Endocrinology Gene Expression Regulation Symporter Cancer research Carrier Proteins business Iodine |
| Zdroj: | Trends in Biochemical Sciences. 26:490-496 |
| ISSN: | 0968-0004 |
| DOI: | 10.1016/s0968-0004(01)01904-1 |
| Popis: | The Na+/I- symporter (NIS) is an intrinsic plasma membrane protein that mediates the active transport of I- in the thyroid, lactating mammary gland, stomach and salivary glands. The presence of NIS in the thyroid is exploited in diagnostic scintigraphic imaging and radioiodide therapy in thyroid cancer. The continued rapid progress in NIS research (aimed at the elucidation of the Na+-dependent I- transport mechanism, the analysis of NIS structure-function relations and the study of the tissue-specific regulation of NIS at all levels), holds potentially far-reaching medical applications beyond thyroid disease, in breast cancer and malignancies in other tissues. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect