Galactomannan armed superparamagnetic iron oxide nanoparticles as a folate receptor targeted multi-functional theranostic agent in the management of cancer
| Autor: | Shiji, R, Manu, M Joseph, Anitha, Sen, Raveendran Pillai, K, Unnikrishnan, Bs, Sreelekha, Tt |
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| Rok vydání: | 2022 |
| Předmět: |
Galactose
Antineoplastic Agents General Medicine Magnetic Resonance Imaging Biochemistry Theranostic Nanomedicine Mannans Mice Folic Acid Methotrexate Structural Biology Cell Line Tumor Neoplasms Animals Humans Nanoparticles Magnetic Iron Oxide Nanoparticles Magnetite Nanoparticles Molecular Biology |
| Zdroj: | International Journal of Biological Macromolecules. 219:740-753 |
| ISSN: | 0141-8130 |
| DOI: | 10.1016/j.ijbiomac.2022.07.185 |
| Popis: | Superparamagnetic iron oxide nanoparticles (SPIONs) represent a versatile class of theranostics with profound applications in biomedicine. An eco-friendly modification of SPIONs was attempted with a 110 kDa galactomannan (PSP001) isolated from the fruit rind of Punica granatum. The PSP001 appended SPIONs favor unique advantages including tumor-targeted accumulation and improved biocompatibility. The antineoplastic agent methotrexate (MTX) was covalently attached with the galactomannan in the SPIONs to yield PSP-IO NPs that demonstrated a reduction-sensitive drug release kinetics favoring MTX accumulation selectively in the tumor cells. Folate receptor (FR) targeted cancer cell uptake followed by the stimuli-responsive release of the payload favored improved biocompatibility and lack of toxicity in BALB/c mice. Superior tumor reduction capacity with marked survival benefits was observed in Ehrlich ascites carcinoma (EAC) bearing solid tumor mice. Phantom imaging of the carrier (PSP-IO) and the drug-loaded (PSP-IO-MTX NPs) nano-constructs generated an r2 relaxivity of 335.3 mM |
| Databáze: | OpenAIRE |
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