Effects of adrenaline, dopamine, serotonin, and different cholinergic agents on smooth muscle preparations from the ansa proximalis coli in cattle: studies in vitro
| Autor: | M. Denac, U. Ballinari, Adrian Steiner |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Serotonin Contraction (grammar) Carbachol Epinephrine Colon Dopamine Bethanechol Pathology and Forensic Medicine Internal medicine Culture Techniques Mole medicine Animals Neurotransmitter Agents General Veterinary Chemistry Muscle Smooth Endocrinology Parasympathomimetics Excitatory postsynaptic potential Cholinergic Cattle Female medicine.drug |
| Zdroj: | Zentralblatt fur Veterinarmedizin. Reihe A. 39(7) |
| ISSN: | 0514-7158 |
| Popis: | The effects of adrenaline, dopamine, serotonin, and different cholinergic agents on isolated muscle strips from the ansa proximalis coli in cattle were studied. Adrenaline (5 x 10(-5) mol/l) evoked a relaxing effect (p < 0.05) on longitudinal and circular muscle strips, mediated via beta- and alpha 1-receptors respectively. High concentration of dopamine (5 x 10(-4) mol/l) caused a non-significant inhibitory effect on longitudinal smooth muscles, which was probably mediated by beta- and not by dopamine-receptors. Serotonin (5 x 10(-5) mol/l) and cisapride (75 x 10(-6) mol/l) had no effect. Carbachol (2 or 10 x 10(-6) mol/l) and bethanechol (5 or 10 x 10(-5) mol/l) caused a dose-dependent (p < 0.05) contraction of both smooth muscle types. This excitatory effect was inhibited (p < 0.05) by metoclopramide (1 x 10(-4) mol/l), as well as the muscarinic agents RS-86 (5 x 10(-5) mol/l) and CGP-37,218 (37.5 or 75 x 10(-6) mol/l). |
| Databáze: | OpenAIRE |
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