| Autor: |
Stefan H. Boese, Evamaria Kinne-Saffran, Hanna Tinel, Rolf K. H. Kinne, Frank Wehner, Birgit Ruhfus |
| Jazyk: |
angličtina |
| Předmět: |
|
| Zdroj: |
Kidney International. (6):1686-1689 |
| ISSN: |
0085-2538 |
| DOI: |
10.1038/ki.1996.248 |
| Popis: |
Osmoregulation in the renal papilla: Membranes, messengers and molecules. This contribution summarizes recent progress in the understanding of the molecular basis of the release of organic osmolytes that occurs when inner medullary cells are confronted with a drop in osmolarity in their environment. For sorbitol release across the basolateral membrane an increase in intracellular calcium seems to be the prominent signal, initiated by G-protein activation, followed by phosphatidylcholine phospholipase activation and generation of arachidonic acid. The increase in betaine permeability is also G-protein dependent but calcium independent, and is restricted to the basal-lateral cell face. Myo-inositol and glycerophosphorylcholine efflux are calcium and G-protein independent and occur both across the apical and basolateral membrane, although to a different extent. Taurine release is also calcium and G-protein independent; a swelling-activated anion channel at the basolateral membrane represents the major efflux pathway. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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