Independent euglycaemic hyperinsulinaemic clamp studies validate clinically applicable formulae to estimate insulin sensitivity in people with type 1 diabetes

Autor:	Andrzej S. Januszewski, Pawel Niedzwiecki, Nirupa Sachithanandan, Glenn M. Ward, Connie S. Karschimkus, David N. O'Neal, Dorota A. Zozulinska-Ziolkiewicz, Aleksandra A. Uruska, Alicia J. Jenkins
Rok vydání:	2022
Předmět:	Endocrinology Diabetes and Metabolism Internal Medicine General Medicine
Zdroj:	Diabetesmetabolic syndrome. 17(1)
ISSN:	1878-0334
Popis:	Low insulin sensitivity (IS) increases Type 1 diabetes (T1D) complication risk and can be estimated by simple formulae developed from complex euglycemic hyperinsulinaemic clamp studies. We aimed to validate these formulae using independent clamp data.Clamps were performed in 104 T1D adults. Measured glucose disposal rate (GDR) was correlated with eGDR and eLog10 M/I calculated by five IS formulae.Correlations ranged between 0.23-0.40. Two IS formulae (by the authors), using age, sex, HDL-C, HbA1c, pulse pressure, BMI, and waist-hip-ratio had the highest correlation with measured GDR and the best performance in detecting low IS.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dedcb78f27bfb05362468c273b89a73 https://pubmed.ncbi.nlm.nih.gov/36586292 Zobrazit plný text záznamu Full Text from ScienceDirect