Myosin heavy chain isoforms in smooth muscle
| Autor: | Evgenij Loukianov, Tanya Loukianova, Muthu Periasamy |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Myosin light-chain kinase
Physiology Molecular Sequence Data Biology Myosins Muscle Development Biochemistry Myosin medicine Myocyte Animals Amino Acid Sequence Vascular Diseases Cloning Molecular Molecular Biology Smooth muscle tissue Myosin Heavy Chains Skeletal muscle Muscle Smooth Anatomy Cell biology Alternative Splicing medicine.anatomical_structure Gene Expression Regulation MYH7 Myofibril ITGA7 |
| Zdroj: | Comparative biochemistry and physiology. Part B, Biochemistrymolecular biology. 117(1) |
| ISSN: | 1096-4959 |
| Popis: | In recent years, significant progress has been made toward understanding smooth muscle myosin heavy chain (SMHC) structure. Molecular cloning analysis has identified four different MHC isoforms. They are products of a single gene and result from alternative mRNA splicing. In addition, two non-muscle MHC isoforms are also expressed in smooth muscle cells. Studies show that SMHC expression is highly tissue specific and does not appear in cardiac or skeletal muscle cells. Each smooth muscle tissue is characterized by a specific pattern of MHC isoform expression that changes during development and disease. This review essentially focuses on SMHC isoforms and their expression in mammals. |
| Databáze: | OpenAIRE |
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