The Role of Phylogenetics in Unravelling Patterns of HIV Transmission towards Epidemic Control: The Quebec Experience (2002–2020)
| Autor: | Brenner, Bluma G., Ibanescu, Ruxandra-Ilinca, Osman, Nathan, Cuadra-Foy, Ernesto, Oliveira, Maureen, Chaillon, Antoine, Stephens, David, Hardy, Isabelle, Routy, Jean-Pierre, Thomas, Réjean, Baril, Jean-Guy, Leblanc, Roger, Tremblay, Cecile, Roger, Michel, Group, The Montreal Primary HIV Infection (PHI) Cohort Study Group The Montreal Primary HIV Infection (PHI) Cohort Study |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male HIV-1 transmission men having sex with men HIV Infections non-B subtypes Biology migration Microbiology Article Young Adult Phylogenetics Virology 80 and over 2.2 Factors relating to the physical environment Humans Men having sex with men Aetiology Homosexuality Male Hiv transmission Epidemics Epidemic control Phylogeny Aged Aged 80 and over Transmission (medicine) Prevention Quebec Homosexuality Middle Aged Treatment as prevention QR1-502 phylogenetics Viral phylodynamics Infectious Diseases Good Health and Well Being HIV-TRACE treatment-as-prevention HIV-1 HIV/AIDS Female Viral spread Infection Demography |
| Zdroj: | Viruses Volume 13 Issue 8 Viruses, vol 13, iss 8 Viruses, Vol 13, Iss 1643, p 1643 (2021) |
| ISSN: | 1999-4915 |
| DOI: | 10.3390/v13081643 |
| Popis: | Phylogenetics has been advanced as a structural framework to infer evolving trends in the regional spread of HIV-1 and guide public health interventions. In Quebec, molecular network analyses tracked HIV transmission dynamics from 2002–2020 using MEGA10-Neighbour-joining, HIV-TRACE, and MicrobeTrace methodologies. Phylogenetics revealed three patterns of viral spread among Men having Sex with Men (MSM, n = 5024) and heterosexuals (HET, n = 1345) harbouring subtype B epidemics as well as B and non-B subtype epidemics (n = 1848) introduced through migration. Notably, half of new subtype B infections amongst MSM and HET segregating as solitary transmissions or small cluster networks (2–5 members) declined by 70% from 2006–2020, concomitant to advances in treatment-as-prevention. Nonetheless, subtype B epidemic control amongst MSM was thwarted by the ongoing genesis and expansion of super-spreader large cluster variants leading to micro-epidemics, averaging 49 members/cluster at the end of 2020. The growth of large clusters was related to forward transmission cascades of untreated early-stage infections, younger at-risk populations, more transmissible/replicative-competent strains, and changing demographics. Subtype B and non-B subtype infections introduced through recent migration now surpass the domestic epidemic amongst MSM. Phylodynamics can assist in predicting and responding to active, recurrent, and newly emergent large cluster networks, as well as the cryptic spread of HIV introduced through migration. |
| Databáze: | OpenAIRE |
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