Setting surface wipe limits for skin sensitizers
| Autor: | Bruce D Naumann, Susan Arnold |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Health
Toxicology and Mutagenesis Cosmetics 010501 environmental sciences Toxicology Risk Assessment 01 natural sciences Mice 03 medical and health sciences 0302 clinical medicine Occupational hygiene Occupational Exposure medicine Animals Humans Sensitization Skin Skin Tests 0105 earth and related environmental sciences Exposure assessment business.industry Local lymph node assay Skin sensitization Skin exposure Public Health Environmental and Occupational Health Local Lymph Node Assay Hazard communication 030210 environmental & occupational health Reliability engineering medicine.anatomical_structure Dermatitis Allergic Contact Occupational exposure business |
| Zdroj: | Toxicology and Industrial Health. 35:614-625 |
| ISSN: | 1477-0393 0748-2337 |
| DOI: | 10.1177/0748233719875365 |
| Popis: | Guidance for managing potential dermal exposures has historically been qualitative in nature, for example, in the form of a DSEN notation. We propose a method that can provide quantitative guidance on how to establish and use surface wipe limits for skin sensitizers. The murine local lymph node assay (LLNA) is a validated test that not only identifies potential skin sensitizers but also provides an effective concentration (EC3) value. This provides quantitative dose–response information on induction of skin sensitization that permits estimates of sensitization thresholds and potency. Building upon the previously established correlation between LLNA EC3 values and human repeat insult patch testing no-effect levels, we present a quantitative method for setting surface wipe guidelines using the LLNA EC3. These limits can be used to assign compounds to occupational exposure bands and provide handling guidance for skin sensitizers of varying potency, supporting both exposure assessment and control strategies. A table is included that suggests a band of reasonable surface wipe limits (mg/100 cm2) for potentially all chemical sensitizers. When used in conjunction with a comprehensive industrial hygiene program that includes hazard communication, engineering controls, and personal protective equipment, skin exposure and consequent skin sensitization risks in the workplace can be minimized. |
| Databáze: | OpenAIRE |
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