Serum Soluble Interleukin-2 Receptor as a Potential Biomarker for Immune-related Adverse Events
| Autor: | Yohei Funakoshi, Yoshihiro Kakeji, Kimihiro Yamashita, Masanori Toyoda, Hirotaka Suto, Ryo Takai, Ken-ichi Harada, Yoshiaki Nagatani, Hironobu Minami, Naomi Kiyota, Kimikazu Yakushijin, Yoshinori Imamura |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Interleukin 2 Cancer Research medicine.medical_specialty Immune checkpoint inhibitors Antibodies Monoclonal Humanized Gastroenterology Immune system Neoplasms Internal medicine Biomarkers Tumor medicine Humans Adverse effect Receptor Immune Checkpoint Inhibitors Aged Aged 80 and over business.industry Cancer Receptors Interleukin-2 General Medicine Middle Aged medicine.disease Ipilimumab Up-Regulation Nivolumab Treatment Outcome Oncology Potential biomarkers Biomarker (medicine) Female business medicine.drug |
| Zdroj: | Anticancer Research. 41:1021-1026 |
| ISSN: | 1791-7530 0250-7005 |
| DOI: | 10.21873/anticanres.14857 |
| Popis: | Background/aim Biomarkers for immune-related adverse events (irAEs) induced by immune checkpoint inhibitors (ICIs) are required. We encountered a patient whose skin irAE fluctuated in parallel with serum soluble interleukin-2 receptor (sIL-2R). Patients and methods We examined 15 patients with cancer who received ICIs. Serum sIL-2R levels before and during ICI treatment were measured. The sIL-2R levels of preserved serum samples from another five patients who developed grade 3 irAEs were measured. Results Twelve patients showed no significant changes in sIL-2R levels during ICI treatment. Baseline serum sIL-2R levels in three patients increased beyond the normal range before the second cycle. These three patients had grade ≥2 irAEs at the second cycle treatment visit, supporting our hypothesis. Furthermore, at diagnosis of irAEs, the sIL-2R levels of all preserved samples from patients with grade 3 irAEs were significantly elevated. Conclusion Serum sIL-2R is a promising biomarker for the diagnosis of irAEs. |
| Databáze: | OpenAIRE |
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