Immunity to Cryptosporidium: Lessons from Acquired and Primary Immunodeficiencies

Autor:	Ian S. Cohn, Sarah E. Henrickson, Boris Striepen, Christopher A. Hunter
Rok vydání:	2022
Předmět:	Diarrhea Immunocompromised Host Immunology Immunologic Deficiency Syndromes Humans Cryptosporidium Cryptosporidiosis Immunology and Allergy
Zdroj:	The Journal of Immunology. 209:2261-2268
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.2200512
Popis:	Cryptosporidium is a ubiquitous protozoan parasite that infects gut epithelial cells and causes self-limited diarrhea in immunocompetent individuals. However, in immunocompromised hosts with global defects in T cell function, this infection can result in chronic, life-threatening disease. In addition, there is a subset of individuals with primary immunodeficiencies associated with increased risk for life-threatening cryptosporidiosis. These patients highlight MHC class II expression, CD40–CD40L interactions, NF-κB signaling, and IL-21 as key host factors required for resistance to this enteric pathogen. Understanding which immune deficiencies do (or do not) lead to increased risk for severe Cryptosporidium may reveal mechanisms of parasite restriction and aid in the identification of novel strategies to manage this common pathogen in immunocompetent and deficient hosts.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da9598f28c430f455ffca0de44d4415 https://doi.org/10.4049/jimmunol.2200512 Zobrazit plný text záznamu