Polio Antibodies and HLA Antigens in Amyotrophic Lateral Sclerosis
| Autor: | Matti Jokelainen, Kaisa Lapinleimu, Anja Tiilikainen |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Immunology Human leukocyte antigen Antibodies Viral Lymphocyte Activation Biochemistry Mitomycins Epitopes 03 medical and health sciences 0302 clinical medicine Antigen HLA Antigens Genetics medicine Humans Immunology and Allergy Neuroepidemiology Lymphocytes Amyotrophic lateral sclerosis Aged biology business.industry Amyotrophic Lateral Sclerosis Antibody titer General Medicine Middle Aged medicine.disease Virology 3. Good health Poliomyelitis Poliovirus biology.protein Female Lymphocyte Culture Test Mixed Antibody business 030217 neurology & neurosurgery Progressive disease 030215 immunology |
| Zdroj: | Tissue Antigens. 10:259-266 |
| ISSN: | 0001-2815 |
| Popis: | Amyotrophic lateral sclerosis (ALS) is a fatal, progressive disease of the central nervous system. Its possible association with poliomyelitis was studied by measuring neutralizing antibodies against polio virus types 1, 2 and 3 in the sera and cerebrospinal fluids of 11 ALS-patients, but antibody titers did not markedly differ from those of the controls. The HLA antigens of 12 ALS patients were also determined, in order to reveal any possible genetically-determined susceptibility to the disease. Possible association of ALS with HLA-Bw40 was noted. In addition, the Bw40 antigen seemed to be associated with milder progression of the disease. The lymphocytes of the ALS patients seemed defective in their capacity to stimulate allogenic lymphocytes, possibly due to a relative decrease of B cells in the peripheral blood. Joint efforts of study groups of neuroepidemiology, immunology and genetics should be mobilized to reveal the true nature of these findings. |
| Databáze: | OpenAIRE |
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