Thrombocytopaenia: a serious side effect of diazoxide
| Autor: | Josefine C van der Heyden, Wilhelmina J den Boogert, Kirsten A Thus |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Side effect 030105 genetics & heredity Gastroenterology 03 medical and health sciences 0302 clinical medicine Hydrochlorothiazide Internal medicine Hyperinsulinism medicine Diazoxide Humans Platelet Antihypertensive Agents business.industry Blood Screening Hematemesis General Medicine medicine.disease Thrombocytopenia Epistaxis Rectal Diseases Child Preschool Congenital hyperinsulinism Drug Therapy Combination business 030217 neurology & neurosurgery medicine.drug Findings That Shed New Light on the Possible Pathogenesis of a Disease or an Adverse Effect |
| Zdroj: | BMJ Case Rep |
| ISSN: | 1757-790X |
| Popis: | A 2.5-year-old boy with a history of (transient) congenital hyperinsulinism was admitted to the paediatric ward with recurrent hypoglycaemia. Diazoxide 5 mg/kg/day and hydrochlorothiazide 2 mg/kg/day were initiated. After increasing the dose of diazoxide to 10 mg/kg/day, the child developed mild rectal bleeding, petechiae, epistaxis and haematemesis. Blood screening showed severe thrombocytopaenia. Diazoxide and hydrochlorothiazide were stopped, and his platelet count normalised. Drug rechallenge was positive. Drug-induced immune thrombocytopaenia was diagnosed. |
| Databáze: | OpenAIRE |
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