Low molecular weight heparin-induced skin necrosis—a systematic review
| Autor: | H. J. Kock, Alexander E. Handschin, Guido A. Wanner, Otmar Trentz |
|---|---|
| Přispěvatelé: | University of Zurich, Handschin, A E |
| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Necrosis Side effect medicine.drug_class Hirudin Low molecular weight heparin 610 Medicine & health Fondaparinux 142-005 142-005 Injections Thromboembolism medicine Humans Skin Multiple Trauma business.industry Anticoagulant Anticoagulants Heparin Heparin Low-Molecular-Weight Middle Aged Dermatology 2746 Surgery Surgery Spinal Fractures medicine.symptom business Complication medicine.drug |
| Zdroj: | Langenbeck's Archives of Surgery. 390:249-254 |
| ISSN: | 1435-2451 1435-2443 |
| DOI: | 10.1007/s00423-004-0522-7 |
| Popis: | Background: Low molecular weight heparins (LMWHs) are currently used as a standard for anti-thrombotic therapy. Skin necrosis caused by LMWH is a rare and probably under-reported complication. The aim of our systematic review is to analyse the present literature for cases of LMWH-induced skin necrosis, emphasising the pathogenesis, clinical pattern, and management of this rare side effect. Methods: We performed a Medline literature search (PubMed database) and manual cross-referencing to identify all articles related to LMWH-induced skin necrosis. Data were analysed for type of LMWH used, time until skin necrosis occurred, localisation, size, laboratory findings, switch anticoagulant, complications, and outcome. Additionally, the case of a patient from our hospital is presented. Results: We included a total of 20 articles (21 cases) reporting on LMWH-induced skin necrosis. Skin necrosis occurred locally and distant from the injection site. Heparin-induced antibodies were frequently observed (positive 9/11 articles, negative 2/11). However, severe thrombocytopenia (platelet count |
| Databáze: | OpenAIRE |
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