Epidemiology and Management of Chronic Thromboembolic Pulmonary Hypertension in Greece. Real-World Data from the Hellenic Pulmonary Hypertension Registry (HOPE)

Autor:	Eftychia Demerouti, Panagiotis Karyofyllis, Vassilios Voudris, Maria Boutsikou, George Anastasiadis, Anastasia Anthi, Alexandra Arvanitaki, George Athanassopoulos, Aikaterini Avgeropoulou, Styliani Brili, Christos Feloukidis, Frantzeska Frantzeskaki, George Karatasakis, Haralambos Karvounis, Dimitrios Konstantonis, Ioanna Mitrouska, Sophia Mouratoglou, Katerina K. Naka, Stylianos E. Orfanos, Evangelia Panagiotidou, Georgia Pitsiou, Antonios Pitsis, Vagia Stamatopoulou, Ioannis Stanopoulos, Adina Thomaidis, Iraklis Tsangaris, Dimitrios Tsiapras, George Giannakoulas, Athanassios Manginas, on behalf of the Hellenic Society for the Study of Pulmonary Hypertension (HSSPH)
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	medicine.medical_specialty medicine.medical_treatment Population pulmonary endarterectomy Cardiac index registry Riociguat Article chronic thromboembolic pulmonary hypertension Angioplasty Internal medicine pulmonary hypertension medicine education education.field_of_study business.industry General Medicine medicine.disease Brain natriuretic peptide Pulmonary hypertension Pulmonary embolism medicine.anatomical_structure Cardiology Vascular resistance Medicine business balloon pulmonary angioplasty medicine.drug
Zdroj:	Journal of Clinical Medicine Journal of Clinical Medicine, Vol 10, Iss 4547, p 4547 (2021) Volume 10 Issue 19
ISSN:	2077-0383
Popis:	Chronic Thromboembolic Pulmonary Hypertension (CTEPH) is a rare disease with poor prognosis if left untreated, characterized by pulmonary vascular bed obstruction due to unresolving thromboembolic material. The Hellenic pulmonary hypertension registry (HOPE) was launched in Greece in early 2015 and enrolls patients from all pulmonary hypertension subgroups in Greece. In total, 98 patients with CTEPH were enrolled from January 2015 until November 2019. Of these patients, 55.1% represented incident population, 50% were classified in the World Health Organization functional class II and 49% had a history of acute pulmonary embolism. The median values of pulmonary vascular resistance (PVR) and cardiac index were 7.4 (4.8) WU and 2.4 (1.0) L/min/m2, respectively, the mean diffusing capacity for carbon monoxide was 74.8 ± 20.6%, the median 6-minute walk distance was 347 (220) meters and the median value of N Terminal-pro brain natriuretic peptide was 506.0 (1450.0) pg/mL. In total, 60.2% of the patients were under pulmonary arterial hypertension-targeted therapy at the time of enrolment specifically, riociguat was received by 35.7% of the patients and combination therapy was the preferred strategy for 16% of the patients. In total, 74 patients were evaluated for pulmonary endarterectomy (PEA), 34 (45.9%) were assessed as operable but only 23 of those (31.1%) finally underwent PEA. The remaining 40 patients were ineligible for PEA according to the operability assessment and 13 (17.6%) of them underwent balloon pulmonary angioplasty. The age of the non-operable patients was significantly higher than the operable patients (p < 0.001), while there was no significant difference with regard to the history of coagulopathies between the operable and non-operable patients (p = 0.33).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d951cccf3c3b467d9a96afac2fe3e52 http://europepmc.org/articles/PMC8509504 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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