Agents from amphibians with anticancer properties
| Autor: | Chuang-Xin Lu, Ke-Jun Nan, Yan Lei |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Amphibian
Biogenic Amines Cancer Research animal structures RNase P Molecular Sequence Data Antineoplastic Agents Apoptosis Biology Toxicology Alkaloids Ribonucleases biology.animal Animals Cytotoxic T cell Pharmacology (medical) Amino Acid Sequence Amphinase Cytotoxicity Skin Pharmacology RNA Bufalin Lectin Bufonidae Bufanolides Oncology Biochemistry embryonic structures biology.protein |
| Zdroj: | Anti-Cancer Drugs. 19:931-939 |
| ISSN: | 0959-4973 |
| DOI: | 10.1097/cad.0b013e3283139100 |
| Popis: | Amphibians have been found to be a source of agents with anticancer properties. Bufalin, for example, is an anticancer agent that may induce apoptosis by its interaction with other genes and cellular components. Certain peptides with anticancer activities have been found in amphibian skin; they include magainins, aureins, citropin 1.1 and gaegurins. These peptides may exert a cytotoxic effect on human cancer cells through various mechanisms. Onconase, amphinase, cSBL (sialic acid-binding lectin purified from Rana catesbeiana eggs) and jSBL (sialic acid-binding lectin purified from Rana japonica eggs), which belong to the RNase A family, were purified from the oocyte cells and eggs of three amphibians, and they induce cytotoxicity by degrading cellular RNA. This paper discusses the medical and pharmaceutical significance of products derived from amphibians. |
| Databáze: | OpenAIRE |
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