Risk Factors for Severe COVID-19 in Children
| Autor: | Fiona P. Havers, Evan J. Anderson, Erica Bye, James Meek, Huong Pham, Kadam Patel, Meredith McMorrow, Rebecca C. Woodruff, Laurie M Billing, Angela P Campbell, Breanna Kawasaki, Shua J Chai, Michael Whitaker, Melissa Sutton, Libby Reeg, Nancy M. Bennett, Christopher A. Taylor, Maya Monroe, Alison Muse, Daniel M. Sosin, H. Keipp Talbot, Keegan McCaffrey, Andy Weigel |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
2019-20 coronavirus outbreak COVID-19 Vaccines Coronavirus disease 2019 (COVID-19) SARS-CoV-2 business.industry Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) MEDLINE COVID-19 Infant Articles Hospitalization Risk Factors Internal medicine Pediatrics Perinatology and Child Health medicine Humans Child business |
| Zdroj: | Pediatrics |
| ISSN: | 1098-4275 0031-4005 |
| DOI: | 10.1542/peds.2021-053418 |
| Popis: | OBJECTIVES Describe population-based rates and risk factors for pediatric severe coronavirus disease 2019 (COVID-19) (ie, ICU admission, invasive mechanical ventilation, or death). METHODS During March 2020 to May 2021, the COVID-19–Associated Hospitalization Surveillance Network identified 3106 children hospitalized with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection in 14 states. Among 2293 children primarily admitted for COVID-19, multivariable generalized estimating equations generated adjusted risk ratios (aRRs) and 95% confidence intervals (CIs) of the associations between demographic and medical characteristics abstracted from patient electronic medical records and severe COVID-19. We calculated age-adjusted cumulative population-based rates of severe COVID-19 among all children. RESULTS Approximately 30% of hospitalized children had severe COVID-19; 0.5% died during hospitalization. Among hospitalized children aged CONCLUSIONS Results identify children at potentially higher risk of severe COVID-19 who may benefit from prevention efforts, including vaccination. Rates establish a baseline for monitoring changes in pediatric illness severity after increased availability of COVID-19 vaccines and the emergence of new variants. |
| Databáze: | OpenAIRE |
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